Efficient ball mill procedure in the green asymmetric aldol reaction
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Efficient ball-mill procedure in the ‘green’ asymmetric
09.09.2011· The organocatalytic activity of (S)-proline-based dipeptides 1a–c has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solvent-free conditions in a ball mill.In particular, the methyl ester of (S)-proline-(S)-tryptophan, (S,S)-1c, proved to be an efficient organocatalyst, and the aldol reaction proceeded with good chemical
Efficient Ball Mill Procedure In The Green Asymmetric
Efficient Ball Mill Procedure In The Green Asyetric Aldol. Efficient ball mill procedure in the green asymmetric . Efficient ball mill procedure in the green asymmetric aldol reaction organocatalyed by S This result is in agreement with expectation that dipeptides of proline and a second hydrophobic residue should be efficient catalysts in aldol reaction due to the possible formation of a
Efficient ball-mill procedure in the ‘green’ asymmetric
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by ( S)-proline-containing dipeptides in the presence of water
A Green and Efficient Asymmetric Aldol Reaction Catalyzed
José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).
ChemInform Abstract: Efficient Ball-Mill Procedure in the
ChemInform Abstract: Efficient Ball-Mill Procedure in the ′Green′ Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline-Containing Dipeptides in the Presence of Water.
Asymmetric Aldol Reaction Organocatalyzed by (S)-Proline
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011,67 (36),6953-6959.
A Green and Efficient Asymmetric Aldol Reaction
José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).
Efficient ball-mill procedure in the ‘green’ asymmetric
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by ( S)-proline-containing dipeptides in the presence of water
Efficient Ball Mill Procedure In The Green Asymmetric
Efficient Ball Mill Procedure In The Green Asymmetric Aldol Reaction. 201134the organocatalytic activity of the methyl ester of sprolinesphenylalanine, s,s2, in the asymmetric aldol reaction between cyclohexanone and acetone with various aromatic aldehydes under solventfree conditions in a ball mill has been evaluated,dipeptide s,s2 catalyzed the stereoselective formation of the expected aldol
Asymmetric Aldol Reaction Organocatalyzed by (S)
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011,67 (36),6953-6959.
Asymmetric Aldol Reaction Organocatalyzed by (S)
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011, 67, 6953-6959. DOI: 10.1016/j.tet.2011.06.042. Jose G. Hernandez, Eusebio Juaristi.
A Highly Efficient Asymmetric Organocatalytic Aldol
Download Citation A Highly Efficient Asymmetric Organocatalytic Aldol Reaction in a Ball Mill Anti-aldol products with up to >99 % enantiomeric excess (ee) have been obtained by proline
The Ion Tag Strategy as a Route to Highly Efficient
José G. Hernández and Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 67, 36, (6953), (2011).
efficient ball mill procedure in the aldol reaction
Solvent-free asymmetric aldol reaction ResearchGate. Nov 3, 2011 An efficient, solvent-free ball-milling protocol for the asymmetric aldol reaction between cyclohexanone For example, in asymmetric aldol reactions the use strated that the efficiency of the process using High Speed Ball-. Get Price. Sample Chapter Wiley-VCH. With respect of the many solid/solid reactions
Polymer‐Immobilized Pyrrolidine‐Based Chiral Ionic Liquids
José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).
Ball Milling University of Massachusetts Boston
Ball Milling An efficient and ecologically friendly synthetic approach Principles of green chemistry Ball milling solvent free approach Conclusion Content 14 . Application in Organic Synthesis Aldol Condensations Knoevenagel Condensations Baylis-Hillman Reaction Michael Reaction Wittig Reaction Fullerene Cycloadditions Suzuki Reaction Heck-Jeffery Reaction Radical Additions Mediated by
A Highly Efficient Asymmetric Organocatalytic Aldol
Download Citation A Highly Efficient Asymmetric Organocatalytic Aldol Reaction in a Ball Mill Anti-aldol products with up to >99 % enantiomeric excess (ee) have been obtained by proline
efficient ball mill procedure in the aldol reaction
Solvent-free asymmetric aldol reaction ResearchGate. Nov 3, 2011 An efficient, solvent-free ball-milling protocol for the asymmetric aldol reaction between cyclohexanone For example, in asymmetric aldol reactions the use strated that the efficiency of the process using High Speed Ball-. Get Price. Sample Chapter Wiley-VCH. With respect of the many solid/solid reactions
Asymmetric Aldol Reaction Organocatalyzed by (S)
Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011, 67, 6953-6959. DOI: 10.1016/j.tet.2011.06.042. Jose G. Hernandez, Eusebio Juaristi.
Solvent-free asymmetric aldol reaction
An efficient, solvent-free ball-milling protocol for the asymmetric aldol reaction between cyclohexanone and cyclopentanone with various aromatic aldehydes using a novel series of (S)-proline-containing dipeptides and thiodipeptides 1a f as organocatalysts is reported.
Solvent-Free Enantioselective Organocatalyzed Aldol
The use of an organic molecule as catalyst to promote a reaction meets several principles of Green Chemistry. The implementation of solvent-free methodologies to carry out the aldol reaction was soon envisaged. These solvent-free processes can be performed using conventional magnetic stirring or applying ball milling techniques and are even compatible with the use of supported organocatalysts
Ball Milling University of Massachusetts Boston
Ball Milling An efficient and ecologically friendly synthetic approach Principles of green chemistry Ball milling solvent free approach Conclusion Content 14 . Application in Organic Synthesis Aldol Condensations Knoevenagel Condensations Baylis-Hillman Reaction Michael Reaction Wittig Reaction Fullerene Cycloadditions Suzuki Reaction Heck-Jeffery Reaction Radical Additions Mediated by
The Ion Tag Strategy as a Route to Highly Efficient
José G. Hernández and Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 67, 36, (6953), (2011).
Solvent-free enantioselective organocatalyzed aldol reactions
solvent-free conditions leading to a ―greener‖ and more sustainable process. Keywords: aldol, enamine, green chemistry, organocatalysis, proline, solvent-free, asymmetric catalysis . 2 1. INTRODUCTION The aldol reaction [1] discovered in 1872 by Wurtz [2] is one of the most important tools in organic chemistry to perform the synthesis of products ranging from simple building blocks to
Investigating Sequence Space: How Important is the
José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).
Polymer‐Immobilized Pyrrolidine‐Based Chiral Ionic
José G. Hernández, Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 10.1016/j.tet.2011.06.042, 67, 36, (6953-6959), (2011).
Mechanochemistry assisted asymmetric organocatalysis: A
Green chemistry involves innovation in chemical research and engineering that encourages the design of Bolm’s group reported a solvent-free asymmetric organocatalytic aldol reaction under ball-milling conditions using L-proline (I) as catalyst (Scheme 1) [29–30]. Various five and six-membered cyclic ketones 1 were reacted with aromatic aldehydes 2 to provide anti-aldol products 3 in
Solvent-Free Enantioselective Organocatalyzed Aldol
The use of an organic molecule as catalyst to promote a reaction meets several principles of Green Chemistry. The implementation of solvent-free methodologies to carry out the aldol reaction was soon envisaged. These solvent-free processes can be performed using conventional magnetic stirring or applying ball milling techniques and are even compatible with the use of supported organocatalysts
Ball Milling University of Massachusetts Boston
Ball Milling An efficient and ecologically friendly synthetic approach Principles of green chemistry Ball milling solvent free approach Conclusion Content 14 . Application in Organic Synthesis Aldol Condensations Knoevenagel Condensations Baylis-Hillman Reaction Michael Reaction Wittig Reaction Fullerene Cycloadditions Suzuki Reaction Heck-Jeffery Reaction Radical Additions Mediated by
ball milling asymmetric organocatalysis
The asymmetric epoxidation reactions,in Solvent-Free Asymmetric Aldol Reactions Under Ball-Milling,Asymmetric organocatalysis mediated by . More information; Solvent . These solvent-free processes can be performed using conventional magnetic stirring or applying ball milling techniques,solvent-free, asymmetric organocatalysis More information; Solvent. Solvent-free synthesis is
Solvent-free enantioselective organocatalyzed aldol reactions
solvent-free conditions leading to a ―greener‖ and more sustainable process. Keywords: aldol, enamine, green chemistry, organocatalysis, proline, solvent-free, asymmetric catalysis . 2 1. INTRODUCTION The aldol reaction [1] discovered in 1872 by Wurtz [2] is one of the most important tools in organic chemistry to perform the synthesis of products ranging from simple building blocks to
Earthworms as a Biocatalyst: In Asymmetric Aldol
The asymmetric direct aldol reaction as one of the most powerful carbon-carbon bond formation methods has become one of the central study issues in organic synthesis. 11 In recent years, a lot of successful metal catalysts and organocatalysts for direct asymmetric aldol reactions have been reported with high efficiency and enantioselectivity, 12 including some methods under solvent-free
Earthworms as a Biocatalyst: In Asymmetric Aldol
A crude extract from earthworms was used as an environmentally friendly and easily accessible biocatalyst for asymmetric direct aldol reactions. The β-hydroxy carbonyl compounds could be prepared in yields of up to 94%, with ee values of up to 98% and dr of up to >99:1. A wide range of substrates could participate in the reaction. This earthworm catalyst was also efficient in the large
Aldol Addition Organic Chemistry
Aldol Addition Aldol Reaction 'Aldol' is an abbreviation of aldehyde and alcohol.When the enolate of an aldehyde or a ketone reacts at the α-carbon with the carbonyl of another molecule under basic or acidic conditions to obtain β-hydroxy aldehyde or ketone, this reaction is called Aldol Reaction.
Highly Diastereo‐ and Enantioselective Direct Aldol
List, Lerner, and Barbas discovered the proline‐mediated aldol reaction in 2000. 13 Since then, many organocatalysts have been developed for several asymmetric reactions. 6,14 Proline is capable of catalyzing the direct aldol reaction in polar organic solvents such as DMSO and DMF. 13,15,16 Recently, Bolm and co‐workers reported that proline catalyzes a solvent‐free asymmetric
Aldol condensation Wikipedia
Aldol condensations are important in organic synthesis, because they provide a good way to form carbon–carbon bonds. For example, the Robinson annulation reaction sequence features an aldol condensation; the Wieland–Miescher ketone product is an important starting material for many organic syntheses. Aldol condensations are also commonly discussed in university level organic chemistry
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